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KMID : 0931320080080010026
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대한상부위장관.헬리코박터학회지
2008 Volume.8 No. 1 p.26 ~ p.31
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Clinicopathologic Characteristics of Multiple Synchronous Gastric Tumors
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Kang Hae-Yeon
Kang Hyoun-Woo
Kim Sang-Gyun
Kim Joo-Sung
Jung Hyun-Chae
Song In-Sung
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Abstract
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Background/Aims: This study was performed to evaluate the clinical and histological differences of background gastric mucosa between single lesion and multiple synchronous lesions in gastric adenoma or early gastric cancer.
Methods: A total of 682 patients with gastric adenoma or early gastric cancer were prospectively enrolled after endoscopic submucosal dissection (ESD) between April 2005 and November 2007. Rapid urease test and biopsies in surrounding normal mucosa of gastric antrum and body were performed to evaluate H. pylori infection and basal histology.
Results: A total of 545 patients with single lesion and 137 patients with multiple synchronous lesions were enrolled. Age of patients with multiple synchronous lesions (64±8 years) was significantly older than patients with single lesion (61±9 years) (p=0.037). In multiple regression analysis, old age and severe intestinal metaplasia of the body was significantly related with multiple synchronous lesions in gastric tumor. However, sex, H. pylori infection and histopathology of adenoma or adenocarcinoma had no significant relationship with multiplicity of lesion.
Conclusions: Multiple synchronous lesions were significantly related with old age and intestinal metaplasia of the body in gastric tumor. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:26-31)
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KEYWORD
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Helicobacter pylori, Intestinal metaplasia, Synchronous lesion, Gastric adenoma, Early gastric cancer
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